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doi: 10.1073/pnas.1418468112. Epub 2015 Mar 23. This plasmid is available through Addgene. Gene: ITPKA - ENSCAFG00000009562 - Canis lupus familiaris (dog) General information. Ensembl ID: ENSCAFG00000009562: Name: ITPKA: Description NCBI Description of ITPKA: Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Summaries for ITPKA gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Sectio Summary: Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4.

ITPKA gene body methylation regulates its expression and thus serves as a novel and potential biomarker for early cancer detection. 1991-11-01 Gene Expression: ITPKA [ NCBI-GEO ] ITPKA [ EBI - ARRAY_EXPRESS ] ITPKA [ SEEK ] ITPKA [ MEM ] Gene Expression Viewer (FireBrowse) ITPKA [ Firebrowse - Broad ] Genevisible: Expression of ITPKA in : [perturbations] BioGPS (Tissue expression) 3706: GTEX Portal (Tissue expression) ITPKA: … Official gene symbol, which is typically a short form of the gene name, according to HGNC. ITPKA (IP3-3KA, IP3KA) Tissue specificityi. The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. Gene. Itpka. Organism.

Plasmid pCNL-N1_ITPKA from Dr. Yasushi Okada's lab contains the insert inositol triphosphate 3-kinase A and is published in Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4352-6.

Instructions A 1 Additional file 1 - Genes differentially regulated by

An important paralog of this gene is ITPKB. ITPKA is a potential oncogene that it is overexpressed in most tumors, and its overexpression promotes tumorigenesis; ITPKA gene body methylation regulates its expression and serves as a novel and potential biomarker for early cancer detection ITPKA is one of three inositol-trisphosphate 3-kinase (ITP3K) genes in humans. ITP3K proteins regulate inositol phosphate metabolism by phosphorylation of the second messenger inositol 1,4,5-trisphosphate to produce Ins (1,3,4,5)P 4, which is sometimes abbreviated as IP 4.

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Wang YW, Ma X, Zhang YA, Wang MJ, Yatabe Y, Lam S, Girard L, Chen JY, Gazdar AF The C-terminal part of ITPKB, namely residues 187 to 462, was 68% identical to ITPKA in amino acid sequence. Mapping By in situ hybridization, Erneux et al.

Next-day shipping cDNA ORF clones derived from ITPKA inositol-trisphosphate 3-kinase A available at GenScript, starting from $99.00. The ITPKC gene provides instructions for making one version (isoform) of the inositol 1,4,5-trisphosphate 3-kinase (ITPK) enzyme. This enzyme helps add a cluster of oxygen and phosphorus atoms (a phosphate group) to a molecule called Ins(1,4,5)P3 to produce a molecule called Ins(1,3,4,5)P4. Inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) is the last identified member of the inositol 1,4,5-trisphosphate 3-kinases… Expand ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers. Wang YW, Ma X, Zhang YA, Wang MJ, Yatabe Y, Lam S, Girard L, Chen JY, Gazdar AF. J Thorac Oncol. ITPKA gene product.
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Protein names. Recommended name: Inositol-trisphosphate 3-kinase A. Short name: IP3K A. Alternative name(s): Inositol 1,4,5-trisphosphate 3-kinase A IP3 3-kinase A InsP 3-kinase A. Top Gene-Substance Gene. Itpka. Species Mouse Transcripts. 1 RefSeq (NM) Transcript Type Coding Product Type Silencer® Select Availability.

To access the transcript level displays select a Transcript ID in the table above and then navigate to the information you want using the menu at the left hand side of the page.
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Among its related pathways are superpathway of inositol phosphate compounds and Metabolism. Gene Ontology (GO) annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is ITPKB.

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ITPKA - Explore an overview of ITPKA, with a histogram displaying coding mutations, full tabulated details of all associated variants, … The protein encoded by the ITPKB gene is one of 3 isoforms of Inositol-trisphosphate 3-kinase expressed in humans. Gene information about ENSG00000137825 / ITPKA - inositol-trisphosphate 3-kinase A Itpka MGI Mouse Gene Detail - MGI:1333822 - inositol 1,4,5-trisphosphate 3-kinase A. View mouse Itpka Chr2:119742337-119751253 with: phenotypes, sequences, polymorphisms, proteins, references, … GuideToPharmacology Gene Category Name: Inositol 1,4,5-trisphosphate 3-kinases: GuideToPharmacology Gene Category ID: 280: Gene Biotype: PROTEIN_CODING Inositol-1,4,5-trisphosphate-3-kinase-A (ITPKA) has recently been found to be implicated in the tumor progression of various cancers. However, the expression and the prognostic value of ITPKA in hepatocellular carcinoma (HCC) remains unexplored. The aim of this study is to investigate the clinical significance of ITPKA expression in HCC. We determined the expression level of ITPKA in 135 cases Despite recent advances in cancer therapy, the overall 5-year survival rate of patients with lung cancer remains low. The aim of our study was to sear… Functional Associations.

Collection, ARCHIVED: Archived Founder gene sets that are referenced by current Hallmarks C2_CP: 8 Jan 2014 Recently, genome-wide association studies have identified allelic variants (A) Immunoblot analysis for ITPKB and ITPKA expression in frontal itpka, itpkb, itpkc, insp3 3-kinase, ip3k, ip3k-a, ip3kb, insp3kinase, ins(1,4,5)p3 kinase, inositol 1,4,5-trisphosphate 3-kinase c, more. top print hide 112 entries 5 May 2014 The single human member is called ITPK1, but should not be confused with the human genes ITPKA, ITPKB and ITPKC, which belong to the Tyrosine-protein kinase ITK/TSK also known as interleukin-2-inducible T-cell kinase or simply ITK, is a protein that in humans is encoded by the ITK gene. ITK is This 12-sample array allows analysis of genetic and structural variation in the human genome, such as duplications, deletions, amplifications, copy-neutral LOH, Learn about mechanism of action for PIQRAY. PIK3CA is the most commonly mutated gene in HR+/ HER2- aBC. See full Prescribing and Safety Info. 7 Jul 2020 (Prokka is a microbial genome annotation tool written in Perl). Genes are first identified with prodigal and the open reading frames blasted in turn ResolveDNA whole genome sequencing solutions provide a clear advantage.